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These ulcers account for more than 80% of non-traumatic lower limb amputations.

The burden of foot ulcer in diabetes varies from 3% in Oceania to 13% in North America, 14.8% in Canada, 5.5% in Asia, and 5.1% in Europe.

The annual incidence of diabetic foot ulcer or necrosis in diabetic patients is known to be about 2-5%.